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01/07/2018

Informing Policy on Ageing

This feature was written by Becky Allen for the Annual ²ÝÁñÉçÇø Report 2017

Ensuring that the Institute’s world-leading research has a direct impact on people’s health means translating – and contextualising – our science for many audiences. For parliamentarians and policy makers, healthy ageing is among the 21^st century’s most pressing problems. So as well as pioneering research on healthy ageing, we’re ensuring science is accessible to decision makers through our knowledge exchange programme.

01/07/2018

The Sounds of the Genome

This feature was written by Becky Allen for the Annual ²ÝÁñÉçÇø Report 2017

The Institute does world-leading research, and using public engagement to enthuse, excite and inspire is a key part of our mission. This year, we teamed up with two innovative artists to transform our data into a virtual reality experience. The result, CHROMOS, is allowing new audiences to discover the DNA drama that goes on inside the nucleus of a single cell.

01/05/2017

Welcome to the 3D genome

This feature was written by Becky Allen for the Annual ²ÝÁñÉçÇø Report 2016

When the first draft of the human genome was published in 2001, it was described as a treasure trove of information. But using that information to understand disease demands going far beyond the DNA code. Now, researchers at the Institute are pioneering a new method of mapping our genome’s complex regulatory interactions that could open up new ways to treat genetic diseases and understand ageing.

01/05/2017

The quiet pathway

This feature was written by Becky Allen for the Annual ²ÝÁñÉçÇø Report 2016

For many years regarded as merely a cell biological process, autophagy is now implicated in many diseases. Thanks to progress made in the Signalling research programme this year autophagy – the mechanism cells use to recycle unwanted or damaged components to create molecules they need – is now understood in greater detail than ever before. We find out how research at the Institute could harness autophagy to help us age more healthily.

01/05/2017

Checks and balances in immune system development

This feature was written by Becky Allen for the Annual ²ÝÁñÉçÇø Report 2016

In 1796, a doctor in rural Gloucestershire took pus from a cowpox lesion on a milkmaid’s hand to inoculate an eight-year-old boy against smallpox. More than 230 years after Edward Jenner’s pioneering vaccination, we still don’t fully understand how our immune system works. Now, researchers in the Institute’s Immunology programme have uncovered a new layer of regulation in immune cells – a discovery that could have far-reaching implications for vaccines, cancer and healthier ageing.

01/05/2017

Unlocking the secrets of early development

This feature was written by Becky Allen for the Annual ²ÝÁñÉçÇø Report 2016

Every cell type in our body results from a different reading of the same genome. Over the past 30 years, scientists have learned that our genes are controlled by epigenetics – a combination of processes that switch genes on and off without altering the DNA sequence itself. But much of epigenetics remains a mystery. The Institute’s Epigenetics programme is exploring the earliest stages of life and how understanding this could help reprogramme cells for regenerative medicine applications in the future.